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UniProt functional annotation for P0ABQ4 | ||
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| UniProt code: P0ABQ4. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
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| Catalytic activity: | |
Reaction=(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH; Xref=Rhea:RHEA:15009, ChEBI:CHEBI:15378, ChEBI:CHEBI:57451, ChEBI:CHEBI:57453, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.5.1.3; Evidence={ECO:0000255|PROSITE- ProRule:PRU00660, ECO:0000269|PubMed:16510443}; |
| Pathway: | |
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8- tetrahydrofolate from 7,8-dihydrofolate: step 1/1. |
| Miscellaneous: | |
The strain K12 sequence is shown. |
| Miscellaneous: | |
Strain B [RT500] is resistant to 500 micrograms per milliliter of trimethoprim. |
| Miscellaneous: | |
Strain B [MB1428] is methotrexate-resistant. |
| Similarity: | |
Belongs to the dihydrofolate reductase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.