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UniProt functional annotation for O75365 | ||
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| UniProt code: O75365. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. {ECO:0000269|PubMed:11355880, ECO:0000269|PubMed:12782572}. |
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| Catalytic activity: | |
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; |
| Activity regulation: | |
Inhibited by sodium orthovanadate and peroxovanadium compounds, and by pentamidine. {ECO:0000269|PubMed:11355880, ECO:0000269|PubMed:12516958}. |
| Subunit: | |
Interacts with tubulin. {ECO:0000269|PubMed:12235145}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:12782572}. Early endosome {ECO:0000269|PubMed:12782572}. |
| Tissue specificity: | |
Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis. {ECO:0000269|PubMed:11355880}. |
| Ptm: | |
Farnesylated. Farnesylation is required for membrane targeting (By similarity). {ECO:0000250}. |
| Miscellaneous: | |
[Isoform 2]: Unstructured and inactive. {ECO:0000305}. |
| Similarity: | |
Belongs to the protein-tyrosine phosphatase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.