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UniProt functional annotation for P35505 | ||
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| UniProt code: P35505. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Catalytic activity: | |
Reaction=4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+); Xref=Rhea:RHEA:10244, ChEBI:CHEBI:13705, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18034, ChEBI:CHEBI:29806; EC=3.7.1.2; Evidence={ECO:0000269|PubMed:11154690, ECO:0000269|PubMed:11209059}; |
| Cofactor: | |
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:11154690, ECO:0000305|PubMed:10508789}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:11154690}; |
| Pathway: | |
Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:10508789, ECO:0000269|PubMed:11154690}. |
| Tissue specificity: | |
Mainly in liver and kidney. |
| Similarity: | |
Belongs to the FAH family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.