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UniProt functional annotation for P15319 | ||
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| UniProt code: P15319. |
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| Organism: | |
Escherichia coli. |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Binds and caps interactive surfaces on P pilus subunits to prevent them from participating in non-productive interactions. Facilitates the import of P pilus subunits into the periplasm, probably also facilitates their folding (PubMed:9351822). Chaperone-subunit complexes are then targeted to the PapC outer membrane usher where the chaperone must uncap from the subunits. Coexpression of this chaperone with individual, otherwise toxic, P pilus subunits (tested with PapA, PapE and PapG) suppresses their growth inhibitory phenotype (PubMed:9351822). {ECO:0000269|PubMed:9351822}. |
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| Subunit: | |
Interacts with substrates PapG and PapK. {ECO:0000269|PubMed:10446050, ECO:0000269|PubMed:9351822}. |
| Subcellular location: | |
Periplasm {ECO:0000269|PubMed:9351822}. |
| Miscellaneous: | |
PapD donates its G1 beta strand to complete the Ig fold of PapK (donor strand complementation). {ECO:0000269|PubMed:2478891}. |
| Similarity: | |
Belongs to the periplasmic pilus chaperone family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.