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UniProt functional annotation for Q9KIZ4 | ||
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| UniProt code: Q9KIZ4. |
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| Organism: | |
Sorangium cellulosum (Polyangium cellulosum). |
| Taxonomy: | |
Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales; Sorangiineae; Polyangiaceae; Sorangium. |
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| Function: | |
Involved in the biosynthesis of epothilones, macrolactones which have a narrow anti-fungal spectrum and microtubule-stabilizing activity. Catalyzes the epoxidation of epothilones C and D to epothilones A and B, respectively. {ECO:0000269|PubMed:10831849}. |
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| Catalytic activity: | |
Reaction=epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]; Xref=Rhea:RHEA:47804, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:31549, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:80029; Evidence={ECO:0000269|PubMed:10831849}; |
| Catalytic activity: | |
Reaction=epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]; Xref=Rhea:RHEA:47808, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29579, ChEBI:CHEBI:31550, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738; Evidence={ECO:0000269|PubMed:10831849}; |
| Cofactor: | |
Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000269|PubMed:12933799}; |
| Pathway: | |
Secondary metabolite biosynthesis; epothilone biosynthesis. {ECO:0000269|PubMed:10831849}. |
| Similarity: | |
Belongs to the cytochrome P450 family. {ECO:0000255|RuleBase:RU000461, ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.