UniProt functional annotation for P35659



	UniProt functional annotation for P35659

UniProt code: P35659.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Involved in chromatin organization. {ECO:0000269|PubMed:17524367}.

Subunit: Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA. {ECO:0000269|PubMed:11118221, ECO:0000269|PubMed:12140263, ECO:0000269|PubMed:16603771}.

Subcellular location: Nucleus {ECO:0000269|PubMed:17524367, ECO:0000269|PubMed:19695025}. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.

Tissue specificity: Ubiquitous. Expressed at relatively high levels.

Ptm: Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase, and weakens the binding of DEK to DNA. {ECO:0000269|PubMed:15199154}.

Disease: Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non- lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK- NUP214 fusion gene (PubMed:1549122). {ECO:0000269|PubMed:1549122}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Involved in chromatin organization. {ECO:0000269\|PubMed:17524367}.


Subunit:		Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA. {ECO:0000269\|PubMed:11118221, ECO:0000269\|PubMed:12140263, ECO:0000269\|PubMed:16603771}.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:17524367, ECO:0000269\|PubMed:19695025}. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.
Tissue specificity:		Ubiquitous. Expressed at relatively high levels.
Ptm:		Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase, and weakens the binding of DEK to DNA. {ECO:0000269\|PubMed:15199154}.
Disease:		Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non- lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK- NUP214 fusion gene (PubMed:1549122). {ECO:0000269\|PubMed:1549122}.