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UniProt functional annotation for P00730 | ||
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| UniProt code: P00730. |
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| Organism: | |
Bos taurus (Bovine). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos. |
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| Function: | |
Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (By similarity). Catalyzes the conversion of leukotriene C4 to leukotriene F4 via the hydrolysis of an amide bond (PubMed:12729612). {ECO:0000250|UniProtKB:P15085, ECO:0000269|PubMed:12729612}. |
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| Catalytic activity: | |
Reaction=Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.; EC=3.4.17.1; Evidence={ECO:0000250|UniProtKB:P15085}; |
| Catalytic activity: | |
Reaction=H2O + leukotriene C4 = glycine + leukotriene F4; Xref=Rhea:RHEA:50740, ChEBI:CHEBI:15377, ChEBI:CHEBI:57305, ChEBI:CHEBI:57973, ChEBI:CHEBI:133618; Evidence={ECO:0000269|PubMed:12729612}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50741; Evidence={ECO:0000269|PubMed:12729612}; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250|UniProtKB:P15085}; Note=Binds 1 zinc ion per subunit. {ECO:0000250|UniProtKB:P15085}; |
| Subunit: | |
Monomer. May form a complex with proelastase 2. {ECO:0000250|UniProtKB:P15085}. |
| Subcellular location: | |
Secreted {ECO:0000250|UniProtKB:P15085}. |
| Tissue specificity: | |
Pancreas. {ECO:0000269|PubMed:7556081}. |
| Similarity: | |
Belongs to the peptidase M14 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.