|
|
||
|
|
|
|
|
UniProt functional annotation for P15555 | ||
|
|
|
|
|
|
||
| UniProt code: P15555. |
|
||
| Organism: | |
Streptomyces sp. (strain R61). |
| Taxonomy: | |
Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces. |
|
||
|
||
| Function: | |
Catalyzes distinct carboxypeptidation and transpeptidation reactions during the last stages of wall peptidoglycan synthesis. Mistaking a beta-lactam antibiotic molecule for a normal substrate (i.e. a D-alanyl-D-alanine-terminated peptide), it becomes immobilized in the form of a long-lived, serine-ester-linked acyl enzyme and thus behave as penicillin-binding protein (PBP). |
|
||
| Catalytic activity: | |
Reaction=Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.; EC=3.4.16.4; |
| Pathway: | |
Cell wall biogenesis; peptidoglycan biosynthesis. |
| Subcellular location: | |
Secreted. |
| Similarity: | |
Belongs to the peptidase S12 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.