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UniProt functional annotation for P00349 | ||
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| UniProt code: P00349. |
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| Organism: | |
Ovis aries (Sheep). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis. |
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| Function: | |
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. |
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| Catalytic activity: | |
Reaction=6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH; Xref=Rhea:RHEA:10116, ChEBI:CHEBI:16526, ChEBI:CHEBI:57783, ChEBI:CHEBI:58121, ChEBI:CHEBI:58349, ChEBI:CHEBI:58759; EC=1.1.1.44; |
| Pathway: | |
Carbohydrate degradation; pentose phosphate pathway; D- ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:15299295, ECO:0000269|PubMed:7922042}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250}. |
| Similarity: | |
Belongs to the 6-phosphogluconate dehydrogenase family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=Ref.2; Type=Miscellaneous discrepancy; Note=Incorrect CNBR peptide order. Many sequencing errors.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.