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UniProt functional annotation for P00959 | ||
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| UniProt code: P00959. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. |
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| Catalytic activity: | |
Reaction=ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L- methionyl-tRNA(Met); Xref=Rhea:RHEA:13481, Rhea:RHEA-COMP:9667, Rhea:RHEA-COMP:9698, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57844, ChEBI:CHEBI:78442, ChEBI:CHEBI:78530, ChEBI:CHEBI:456215; EC=6.1.1.10; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:11243794}. |
| Subcellular location: | |
Cytoplasm. |
| Similarity: | |
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAA60526.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.