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PDBsum entry 1pdr
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Signal transduction
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PDB id
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1pdr
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References listed in PDB file
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Key reference
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Title
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Crystal structure of a pdz domain.
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Authors
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J.H.Morais cabral,
C.Petosa,
M.J.Sutcliffe,
S.Raza,
O.Byron,
F.Poy,
S.M.Marfatia,
A.H.Chishti,
R.C.Liddington.
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Ref.
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Nature, 1996,
382,
649-652.
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PubMed id
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Abstract
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PDZ domains (also known as DHR domains or GLGF repeats) are approximately
90-residue repeats found in a number of proteins implicated in ion-channel and
receptor clustering, and the linking of receptors to effector enzymes. PDZ
domains are protein-recognition modules; some recognize proteins containing the
consensus carboxy-terminal tripeptide motif S/TXV with high specificity. Other
PDZ domains form homotypic dimers: the PDZ domain of the neuronal enzyme nitric
oxide synthase binds to the PDZ domain of PSD-95, an interaction that has been
implicated in its synaptic association. Here we report the crystal structure of
the third PDZ domain of the human homologue of the Drosophila discs-large
tumour-suppressor gene product, DlgA. It consists of a five-stranded
antiparallel beta-barrel flanked by three alpha-helices. A groove runs over the
surface of the domain, ending in a conserved hydrophobic pocket and a buried
arginine; we suggest that this is the binding site for the C-terminal peptide.
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Secondary reference #1
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Title
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Clustering membrane proteins: it'S all coming together with the psd-95/sap90 protein family.
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Author
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S.N.Gomperts.
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Ref.
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Cell, 1996,
84,
659-662.
[DOI no: ]
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PubMed id
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Figure 1.
Figure 1. Domain Map of PSD-95/SAP90All members of the
PSD-95/SAP90 protein family share this domain sequence. PDZ,
SH3, and yeast guanylate kinase homology (GuK) domains are
indicated.
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Figure 2.
Figure 2. Two Possible Models for the Clustering of
Shaker-Type Potassium Channels and PSD-95/SAP90The tetrameric
structure of the potassium channel permits interaction with
multiple PSD-95/SAP90 proteins.(A) Because each Shaker-type
subunit can bind PSD-95/SAP90 at either of its first two PDZ
domains, one PSD-95/SAP90 molecule tethers two channels
together.(B) PSD-95/SAP90 multimers aggregate with Shaker-type
subunits.Note that these models are not mutually exclusive.
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The above figures are
reproduced from the cited reference
with permission from Cell Press
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Secondary reference #2
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Title
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Dhr domains in syntrophins, Neuronal no synthases and other intracellular proteins.
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Authors
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C.P.Ponting,
C.Phillips.
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Ref.
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Trends Biochem Sci, 1995,
20,
102-103.
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PubMed id
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Secondary reference #3
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Title
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Clustering of shaker-Type k+ channels by interaction with a family of membrane-Associated guanylate kinases.
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Authors
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E.Kim,
M.Niethammer,
A.Rothschild,
Y.N.Jan,
M.Sheng.
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Ref.
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Nature, 1995,
378,
85-88.
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PubMed id
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