UniProt functional annotation for P03508



	UniProt functional annotation for P03508

UniProt code: P03508.

Organism: Influenza A virus (strain A/Puerto Rico/8/1934 H1N1).

Taxonomy: Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.

Function: Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs bound to the protein M1. Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced. {ECO:0000255|HAMAP-Rule:MF_04067}.

Subunit: Interacts with protein M1. May interact with host nucleoporin RAB/HRB and exportin XPO1/CRM1. {ECO:0000255|HAMAP-Rule:MF_04067}.

Subcellular location: Virion {ECO:0000255|HAMAP-Rule:MF_04067}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04067}.

Miscellaneous: Average number present in a viral particle is estimated to be 130-200 molecules.

Similarity: Belongs to the influenza viruses NEP family. {ECO:0000255|HAMAP-Rule:MF_04067}.

Annotations taken from UniProtKB at the EBI.


Organism:		Influenza A virus (strain A/Puerto Rico/8/1934 H1N1).
Taxonomy:		Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus.



Function:		Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs bound to the protein M1. Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced. {ECO:0000255\|HAMAP-Rule:MF_04067}.


Subunit:		Interacts with protein M1. May interact with host nucleoporin RAB/HRB and exportin XPO1/CRM1. {ECO:0000255\|HAMAP-Rule:MF_04067}.
Subcellular location:		Virion {ECO:0000255\|HAMAP-Rule:MF_04067}. Host nucleus {ECO:0000255\|HAMAP-Rule:MF_04067}.
Miscellaneous:		Average number present in a viral particle is estimated to be 130-200 molecules.
Similarity:		Belongs to the influenza viruses NEP family. {ECO:0000255\|HAMAP-Rule:MF_04067}.