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UniProt functional annotation for P40482 | ||
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| UniProt code: P40482. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SEC24 specifically recruits cargo proteins like BET1 or SYS1 to the COPII vesicles. The SEC23/24 complex is also involved in internalisation of plasma membrane proteins like the maltose transporter. {ECO:0000269|PubMed:10198022, ECO:0000269|PubMed:10712514, ECO:0000269|PubMed:10720463, ECO:0000269|PubMed:10749860, ECO:0000269|PubMed:10753972, ECO:0000269|PubMed:11086000, ECO:0000269|PubMed:12655150, ECO:0000269|PubMed:12941277, ECO:0000269|PubMed:14627716, ECO:0000269|PubMed:16269340, ECO:0000269|PubMed:8548805, ECO:0000269|PubMed:9023343, ECO:0000269|PubMed:9428766}. |
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| Subunit: | |
The COPII coat is composed of at least 7 proteins: the SEC23/24 complex, the SEC13/31 complex, SFB2, SFB3 and the protein SAR1. Interacts with BET1, EMP24, GRH1, SEC22, SED5 and SYS1. {ECO:0000269|PubMed:10097109, ECO:0000269|PubMed:10564255, ECO:0000269|PubMed:11086000, ECO:0000269|PubMed:11389436, ECO:0000269|PubMed:11560939, ECO:0000269|PubMed:11726510, ECO:0000269|PubMed:12239560, ECO:0000269|PubMed:12778054, ECO:0000269|PubMed:12941276, ECO:0000269|PubMed:12941277, ECO:0000269|PubMed:16269340, ECO:0000269|PubMed:17261844, ECO:0000269|PubMed:8930902, ECO:0000269|PubMed:9325247, ECO:0000269|PubMed:9568718, ECO:0000269|PubMed:9685263}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:8548805}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:10720463, ECO:0000269|PubMed:10753972, ECO:0000269|PubMed:11086000, ECO:0000269|PubMed:12235121, ECO:0000269|PubMed:8548805, ECO:0000269|PubMed:9568718}; Peripheral membrane protein {ECO:0000269|PubMed:11086000, ECO:0000269|PubMed:8548805}; Cytoplasmic side {ECO:0000269|PubMed:8548805}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10712514, ECO:0000269|PubMed:8548805}; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane {ECO:0000305|PubMed:8548805}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. |
| Similarity: | |
Belongs to the SEC23/SEC24 family. SEC24 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.