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UniProt functional annotation for P12993 | ||
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| UniProt code: P12993. |
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| Organism: | |
Staphylococcus aureus. |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae; Staphylococcus. |
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| Function: | |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines (PubMed:24194959). Causes also the intoxication staphylococcal food poisoning syndrome (PubMed:20394711). {ECO:0000269|PubMed:20394711, ECO:0000269|PubMed:24194959}. |
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| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. The zinc ion is necessary for the toxin interaction with MHC class II. {ECO:0000250}; |
| Subunit: | |
Interacts with host MHC class II molecules composed of alpha/HLA-DRA and beta/HLA-DRB1 chains (PubMed:24194959). Interacts with host T-cell receptor beta variable TRBV7-9 (PubMed:24194959, PubMed:26147596, PubMed:27180909). {ECO:0000269|PubMed:24194959, ECO:0000269|PubMed:26147596, ECO:0000269|PubMed:27180909}. |
| Subcellular location: | |
Secreted. |
| Similarity: | |
Belongs to the staphylococcal/streptococcal toxin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.