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PDBsum entry 1od8
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Hydrolase/lectin
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PDB id
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1od8
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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A xylobiose-Derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer.
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Authors
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T.Gloster,
S.J.Williams,
C.A.Tarling,
S.Roberts,
C.Dupont,
P.Jodoin,
F.Shareck,
S.G.Withers,
G.J.Davies.
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Ref.
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Chem Commun (camb), 2003,
8,
944-945.
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PubMed id
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Abstract
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The atomic-resolution structure of a xylobiose-derived isofagomine lactam in
complex with the xylanase Xyn10A from Streptomyces lividans reveals that the
lactam is bound to the enzyme as the amide tautomer, with "reversed"
protonation-states for nucleophile and acid-base.
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