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UniProt functional annotation for P27989 | ||
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| UniProt code: P27989. |
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| Organism: | |
Moorella thermoacetica (Clostridium thermoaceticum). |
| Taxonomy: | |
Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales; Thermoanaerobacteraceae; Moorella group; Moorella. |
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| Function: | |
The beta subunit (this protein) generates CO from CO(2), while the alpha subunit combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl- CoA, is transferred to the alpha subunit by a corrinoid iron-sulfur protein. {ECO:0000269|PubMed:12386327, ECO:0000269|PubMed:12627225}. |
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| Catalytic activity: | |
Reaction=CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]; Xref=Rhea:RHEA:21040, Rhea:RHEA- COMP:10000, Rhea:RHEA-COMP:10001, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17245, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738; EC=1.2.7.4; Evidence={ECO:0000269|PubMed:12627225}; |
| Cofactor: | |
Name=[Ni-Fe-S] cluster; Xref=ChEBI:CHEBI:60400; Note=Binds 1 [Ni-Fe-S] cluster per subunit.; |
| Cofactor: | |
Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 2 [4Fe-4S] clusters per homodimer.; |
| Subunit: | |
Tetramer of two alpha and two beta chains. |
Annotations taken from UniProtKB at the EBI.