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UniProt functional annotation for P06129 | ||
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| UniProt code: P06129. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans- periplasmic membrane protein TonB. Is also a receptor for bacteriophages BF23 and C1, and for A and E colicins. {ECO:0000269|PubMed:10485884, ECO:0000269|PubMed:2687240, ECO:0000269|PubMed:2982793}. |
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| Activity regulation: | |
Calcium increases vitamin B12 binding affinity by a factor of 50-100. {ECO:0000269|PubMed:14499604}. |
| Subunit: | |
Interacts with TonB. {ECO:0000269|PubMed:10485884, ECO:0000269|PubMed:14528295}. |
| Subcellular location: | |
Cell outer membrane {ECO:0000269|PubMed:12595710, ECO:0000269|PubMed:12652322, ECO:0000269|PubMed:2687240, ECO:0000269|PubMed:2982793}; Multi-pass membrane protein {ECO:0000269|PubMed:12595710, ECO:0000269|PubMed:12652322, ECO:0000269|PubMed:2687240, ECO:0000269|PubMed:2982793}. |
| Induction: | |
Constitutively expressed. Primary control of btuB expression by cobalamin occurs at the level of translation initiation. {ECO:0000269|PubMed:9852020}. |
| Similarity: | |
Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily. {ECO:0000255|HAMAP-Rule:MF_01531, ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.