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UniProt functional annotation for P83686 | ||
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| UniProt code: P83686. |
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| Organism: | |
Sus scrofa (Pig). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus. |
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| Function: | |
Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. {ECO:0000305}. |
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| Catalytic activity: | |
Reaction=2 [Fe(III)-cytochrome b5] + NADH = 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+); Xref=Rhea:RHEA:46680, Rhea:RHEA-COMP:10438, Rhea:RHEA- COMP:10439, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.6.2.2; |
| Cofactor: | |
Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000269|PubMed:7890048}; |
| Subunit: | |
Component of a complex composed of cytochrome b5, NADH- cytochrome b5 reductase (CYB5R3) and MTARC2 (PubMed:16973608). Interacts with MTLN; the interaction is required to maintain cellular lipid composition and leads to stimulation of mitochondrial respiratory complex I activity (By similarity). {ECO:0000250|UniProtKB:Q9DCN2, ECO:0000269|PubMed:16973608}. |
| Subcellular location: | |
Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P00387}; Lipid-anchor {ECO:0000250|UniProtKB:P00387}; Cytoplasmic side {ECO:0000250|UniProtKB:P00387}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:P00387}; Lipid-anchor {ECO:0000250|UniProtKB:P00387}; Cytoplasmic side {ECO:0000250|UniProtKB:P00387}. Cytoplasm {ECO:0000250|UniProtKB:P00387}. Note=The enzyme exists in two forms, a membrane-bound form on the cytoplasmic side of the endoplasmic reticulum and also on the mitochondrial outer membrane and in soluble form in erythrocytes. NADH-cytochrome b5 reductase 3 membrane-bound form: Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side. Mitochondrion outer membrane; Lipid-anchor; Cytoplasmic side. NADH- cytochrome b5 reductase 3 soluble form: Cytoplasm. {ECO:0000250|UniProtKB:P00387}. |
| Similarity: | |
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.