|
|
||
|
|
|
|
|
UniProt functional annotation for P47934 | ||
|
|
|
|
|
|
||
| UniProt code: P47934. |
|
||
| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
|
||
|
||
| Function: | |
Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta- oxidation. Responsible for the synthesis of short- and branched-chain acylcarnitines. Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates. Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates. {ECO:0000250|UniProtKB:P43155}. |
|
||
| Catalytic activity: | |
Reaction=(R)-carnitine + acetyl-CoA = CoA + O-acetyl-(R)-carnitine; Xref=Rhea:RHEA:21136, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57589; EC=2.3.1.7; Evidence={ECO:0000250|UniProtKB:P43155}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21137; Evidence={ECO:0000250|UniProtKB:P43155}; |
| Catalytic activity: | |
Reaction=(R)-carnitine + propanoyl-CoA = CoA + O-propanoyl-(R)- carnitine; Xref=Rhea:RHEA:44976, ChEBI:CHEBI:16347, ChEBI:CHEBI:53210, ChEBI:CHEBI:57287, ChEBI:CHEBI:57392; Evidence={ECO:0000250|UniProtKB:P43155}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44977; Evidence={ECO:0000250|UniProtKB:P43155}; |
| Catalytic activity: | |
Reaction=(R)-carnitine + butanoyl-CoA = CoA + O-butanoyl-(R)-carnitine; Xref=Rhea:RHEA:44980, ChEBI:CHEBI:16347, ChEBI:CHEBI:21949, ChEBI:CHEBI:57287, ChEBI:CHEBI:57371; Evidence={ECO:0000250|UniProtKB:P43155}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44981; Evidence={ECO:0000250|UniProtKB:P43155}; |
| Catalytic activity: | |
Reaction=(R)-carnitine + hexanoyl-CoA = CoA + O-hexanoyl-(R)-carnitine; Xref=Rhea:RHEA:44972, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:62620, ChEBI:CHEBI:84834; Evidence={ECO:0000250|UniProtKB:P43155}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44973; Evidence={ECO:0000250|UniProtKB:P43155}; |
| Catalytic activity: | |
Reaction=(R)-carnitine + octanoyl-CoA = CoA + O-octanoyl-(R)-carnitine; Xref=Rhea:RHEA:17177, ChEBI:CHEBI:16347, ChEBI:CHEBI:18102, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386; EC=2.3.1.137; Evidence={ECO:0000250|UniProtKB:P43155}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17178; Evidence={ECO:0000250|UniProtKB:P43155}; |
| Catalytic activity: | |
Reaction=(R)-carnitine + decanoyl-CoA = CoA + O-decanoyl-(R)-carnitine; Xref=Rhea:RHEA:44828, ChEBI:CHEBI:16347, ChEBI:CHEBI:28717, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430; Evidence={ECO:0000250|UniProtKB:P43155}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44829; Evidence={ECO:0000250|UniProtKB:P43155}; |
| Catalytic activity: | |
Reaction=(R)-carnitine + 3-methylbutanoyl-CoA = CoA + O-3- methylbutanoyl-(R)-carnitine; Xref=Rhea:RHEA:44984, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:57345, ChEBI:CHEBI:70819; Evidence={ECO:0000250|UniProtKB:P43155}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44985; Evidence={ECO:0000250|UniProtKB:P43155}; |
| Catalytic activity: | |
Reaction=(R)-carnitine + 2-methylpropanoyl-CoA = CoA + O-isobutanoyl- (R)-carnitine; Xref=Rhea:RHEA:44988, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:57338, ChEBI:CHEBI:84838; Evidence={ECO:0000250|UniProtKB:P43155}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44989; Evidence={ECO:0000250|UniProtKB:P43155}; |
| Catalytic activity: | |
Reaction=(R)-carnitine + 2-methylbutanoyl-CoA = CoA + O-2- methylbutanoyl-(R)-carnitine; Xref=Rhea:RHEA:44992, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:57336, ChEBI:CHEBI:84840; Evidence={ECO:0000250|UniProtKB:P43155}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44993; Evidence={ECO:0000250|UniProtKB:P43155}; |
| Catalytic activity: | |
Reaction=(R)-carnitine + acetoacetyl-CoA = CoA + O-3-oxobutanoyl-(R)- carnitine; Xref=Rhea:RHEA:44996, ChEBI:CHEBI:16347, ChEBI:CHEBI:57286, ChEBI:CHEBI:57287, ChEBI:CHEBI:84841; Evidence={ECO:0000250|UniProtKB:P43155}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44997; Evidence={ECO:0000250|UniProtKB:P43155}; |
| Catalytic activity: | |
Reaction=(R)-carnitine + 3-hydroxybutanoyl-CoA = CoA + O-3- hydroxybutanoyl-(R)-carnitine; Xref=Rhea:RHEA:45000, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:78611, ChEBI:CHEBI:84842; Evidence={ECO:0000250|UniProtKB:P43155}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45001; Evidence={ECO:0000250|UniProtKB:P43155}; |
| Catalytic activity: | |
Reaction=(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8- dimethylnonanoyl-(R)-carnitine; Xref=Rhea:RHEA:44860, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:77061, ChEBI:CHEBI:84654; Evidence={ECO:0000250|UniProtKB:P43155}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44861; Evidence={ECO:0000250|UniProtKB:P43155}; |
| Catalytic activity: | |
Reaction=(R)-carnitine + 2,6-dimethylheptanoyl-CoA = CoA + O-2,6- dimethylheptanoyl-(R)-carnitine; Xref=Rhea:RHEA:45004, ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:84843, ChEBI:CHEBI:84847; Evidence={ECO:0000250|UniProtKB:P43155}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45005; Evidence={ECO:0000250|UniProtKB:P43155}; |
| Subunit: | |
Monomer. {ECO:0000269|PubMed:12526798, ECO:0000269|PubMed:15155726}. |
| Subcellular location: | |
Endoplasmic reticulum {ECO:0000305}. Peroxisome {ECO:0000305}. Mitochondrion inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}. |
| Similarity: | |
Belongs to the carnitine/choline acetyltransferase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.