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UniProt functional annotation for P53610 | ||
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| UniProt code: P53610. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of proteins with the C-terminal sequence Cys-aliphatic- aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B. {ECO:0000269|PubMed:14609943}. |
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| Catalytic activity: | |
Reaction=geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:21240, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11537, ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:57533, ChEBI:CHEBI:86021; EC=2.5.1.59; Evidence={ECO:0000269|PubMed:14609943}; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:14609943, ECO:0000269|PubMed:15248757, ECO:0000269|PubMed:15451670}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:14609943, ECO:0000269|PubMed:15248757, ECO:0000269|PubMed:15451670}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P18898}; |
| Subunit: | |
Heterodimer of FNTA and PGGT1B. PGGT1B mediates interaction with substrate peptides. {ECO:0000269|PubMed:14609943, ECO:0000269|PubMed:15248757, ECO:0000269|PubMed:15451670}. |
| Similarity: | |
Belongs to the protein prenyltransferase subunit beta family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.