UniProt functional annotation for P49356



	UniProt functional annotation for P49356

UniProt code: P49356.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. {ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8494894}.

Catalytic activity: Reaction=(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:13345, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11535, ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:86019, ChEBI:CHEBI:175763; EC=2.5.1.58; Evidence={ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8494894};

Cofactor: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:11687658, ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:15451670, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:11687658, ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:15451670, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009};

Subunit: Heterodimer of FNTA and FNTB. {ECO:0000269|PubMed:11687658, ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:15451670, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8494894}.

Similarity: Belongs to the protein prenyltransferase subunit beta family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. {ECO:0000269\|PubMed:12036349, ECO:0000269\|PubMed:12825937, ECO:0000269\|PubMed:16893176, ECO:0000269\|PubMed:19246009, ECO:0000269\|PubMed:8494894}.


Catalytic activity:		Reaction=(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:13345, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11535, ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:86019, ChEBI:CHEBI:175763; EC=2.5.1.58; Evidence={ECO:0000269\|PubMed:12036349, ECO:0000269\|PubMed:12825937, ECO:0000269\|PubMed:16893176, ECO:0000269\|PubMed:19246009, ECO:0000269\|PubMed:8494894};
Cofactor:		Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269\|PubMed:11687658, ECO:0000269\|PubMed:12036349, ECO:0000269\|PubMed:12825937, ECO:0000269\|PubMed:15451670, ECO:0000269\|PubMed:16893176, ECO:0000269\|PubMed:19246009}; Note=Binds 1 zinc ion per subunit. {ECO:0000269\|PubMed:11687658, ECO:0000269\|PubMed:12036349, ECO:0000269\|PubMed:12825937, ECO:0000269\|PubMed:15451670, ECO:0000269\|PubMed:16893176, ECO:0000269\|PubMed:19246009};
Subunit:		Heterodimer of FNTA and FNTB. {ECO:0000269\|PubMed:11687658, ECO:0000269\|PubMed:12036349, ECO:0000269\|PubMed:12825937, ECO:0000269\|PubMed:15451670, ECO:0000269\|PubMed:16893176, ECO:0000269\|PubMed:19246009, ECO:0000269\|PubMed:8494894}.
Similarity:		Belongs to the protein prenyltransferase subunit beta family. {ECO:0000305}.