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UniProt functional annotation for P11666 | ||
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| UniProt code: P11666. |
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| Organism: | |
Escherichia coli O157:H7. |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage; as the membrane is depolarized, less tension is required to open the channel and vice versa. The channel is characterized by short bursts of activity that last for a few seconds. {ECO:0000250|UniProtKB:P0C0S1}. |
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| Subunit: | |
Homoheptamer. {ECO:0000250|UniProtKB:P0C0S1}. |
| Subcellular location: | |
Cell inner membrane {ECO:0000250|UniProtKB:P0C0S1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P0C0S1}. |
| Similarity: | |
Belongs to the MscS (TC 1.A.23) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.