|
|
||
|
|
|
|
|
UniProt functional annotation for P25774 | ||
|
|
|
|
|
|
||
| UniProt code: P25774. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (PubMed:30612035). The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L. {ECO:0000269|PubMed:30612035}. |
|
||
| Catalytic activity: | |
Reaction=Similar to cathepsin L, but with much less activity on Z-Phe- Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.; EC=3.4.22.27; |
| Subunit: | |
Monomer. {ECO:0000269|PubMed:17469812}. |
| Subcellular location: | |
Lysosome {ECO:0000269|PubMed:1377692}. Secreted {ECO:0000269|PubMed:9524075}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:30612035}. |
| Similarity: | |
Belongs to the peptidase C1 family. {ECO:0000255|PROSITE- ProRule:PRU10088, ECO:0000255|PROSITE-ProRule:PRU10089, ECO:0000255|PROSITE-ProRule:PRU10090}. |
Annotations taken from UniProtKB at the EBI.