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UniProt functional annotation for P04789 | ||
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| UniProt code: P04789. |
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| Organism: | |
Trypanosoma brucei brucei. |
| Taxonomy: | |
Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina; Trypanosomatida; Trypanosomatidae; Trypanosoma. |
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| Catalytic activity: | |
Reaction=D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate; Xref=Rhea:RHEA:18585, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776; EC=5.3.1.1; |
| Pathway: | |
Carbohydrate biosynthesis; gluconeogenesis. |
| Pathway: | |
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate from glycerone phosphate: step 1/1. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:11997014, ECO:0000269|PubMed:2062828, ECO:0000269|PubMed:8591044}. |
| Subcellular location: | |
Glycosome. |
| Miscellaneous: | |
The enzyme contains a high proportion of positively- charged residues in beta-barrels V and VII (compared to the homologous regions in other triose isomerase sequences). Since 2 clusters of positive charges located at precise distances on the molecular surface are common to 4 glycosomal enzymes, it has been speculated that this might represent a signal for entry into glycosomes (PubMed:3015595). {ECO:0000305|PubMed:3015595}. |
| Similarity: | |
Belongs to the triosephosphate isomerase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.