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UniProt functional annotation for P13500 | ||
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| UniProt code: P13500. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:9837883, PubMed:10587439, PubMed:10529171). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:9837883, PubMed:10587439). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8627182, PubMed:9792674, PubMed:8195247). May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (PubMed:8107690). {ECO:0000269|PubMed:10529171, ECO:0000269|PubMed:10587439, ECO:0000269|PubMed:8107690, ECO:0000269|PubMed:8195247, ECO:0000269|PubMed:8627182, ECO:0000269|PubMed:9792674, ECO:0000269|PubMed:9837883}. |
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| Subunit: | |
Monomer or homodimer; in equilibrium (PubMed:8898111, PubMed:9837883, PubMed:15033992, PubMed:8989326). Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans (PubMed:9792674). {ECO:0000269|PubMed:15033992, ECO:0000269|PubMed:8898111, ECO:0000269|PubMed:8989326, ECO:0000269|PubMed:9792674, ECO:0000269|PubMed:9837883}. |
| Subcellular location: | |
Secreted {ECO:0000269|PubMed:23955712, ECO:0000269|PubMed:2513477}. |
| Tissue specificity: | |
Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level) (PubMed:23765988). Expressed in monocytes (PubMed:2513477). {ECO:0000269|PubMed:23765988, ECO:0000269|PubMed:2513477}. |
| Induction: | |
Up-regulated upon hypertonic conditions (PubMed:23233732). In pancreatic islets, secretion is stimulated by IL1B (PubMed:23955712). {ECO:0000269|PubMed:23233732, ECO:0000269|PubMed:23955712}. |
| Ptm: | |
Processing at the N-terminus can regulate receptor and target cell selectivity (PubMed:8627182). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (PubMed:8627182). {ECO:0000269|PubMed:8627182}. |
| Ptm: | |
N-Glycosylated. {ECO:0000269|PubMed:2513477}. |
| Polymorphism: | |
Genetic variations in CCL2 determine Mycobacterium tuberculosis susceptibility [MIM:607948]. {ECO:0000269|PubMed:16352737}. |
| Similarity: | |
Belongs to the intercrine beta (chemokine CC) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.