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UniProt functional annotation for P0A004 | ||
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| UniProt code: P0A004. |
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| Organism: | |
Staphylococcus aureus. |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae; Staphylococcus. |
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| Function: | |
Catalyzes the production of nitric oxide. {ECO:0000250|UniProtKB:O34453}. |
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| Catalytic activity: | |
Reaction=2 L-arginine + 4 O2 + 3 reduced [flavodoxin] = 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]; Xref=Rhea:RHEA:52324, Rhea:RHEA-COMP:10622, Rhea:RHEA-COMP:10623, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16480, ChEBI:CHEBI:32682, ChEBI:CHEBI:57618, ChEBI:CHEBI:57743, ChEBI:CHEBI:58210; EC=1.14.14.47; Evidence={ECO:0000250|UniProtKB:O34453}; |
| Cofactor: | |
Name=heme; Xref=ChEBI:CHEBI:30413; |
| Cofactor: | |
Name=(6S)-5,6,7,8-tetrahydrofolate; Xref=ChEBI:CHEBI:57453; Evidence={ECO:0000250|UniProtKB:O34453}; |
| Subunit: | |
Homodimer. |
| Miscellaneous: | |
This protein is similar to the oxygenase domain of eukaryotic nitric oxide synthases but lacks the reductase domain which, in eukaryotes, is responsible for transfer of electrons to the ferric heme during nitric oxide synthesis. |
| Similarity: | |
Belongs to the NOS family. Bacterial NOS oxygenase subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.