|
|
||
|
|
|
|
|
UniProt functional annotation for P60043 | ||
|
|
|
|
|
|
||
| UniProt code: P60043. |
|
||
| Organism: | |
Naja sagittifera (Andaman cobra). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Naja. |
|
||
|
||
| Function: | |
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. |
|
||
| Catalytic activity: | |
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000255|PROSITE-ProRule:PRU10035, ECO:0000255|PROSITE- ProRule:PRU10036}; |
| Cofactor: | |
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000305|PubMed:15828003}; Note=Binds 1 Ca(2+) ion. {ECO:0000305|PubMed:15828003}; |
| Subunit: | |
Heterodimer formed between two homologous isoforms: isoform 1 and isoform 2. {ECO:0000269|PubMed:15828003}. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Similarity: | |
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.