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UniProt functional annotation for Q8ZNF3 | ||
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| UniProt code: Q8ZNF3. |
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| Organism: | |
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella. |
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| Function: | |
Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) (PubMed:12429098, PubMed:24460375). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity). {ECO:0000250, ECO:0000269|PubMed:12429098, ECO:0000269|PubMed:24460375}. |
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| Catalytic activity: | |
Reaction=2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose = L- glutamate + UDP-beta-L-threo-pentopyranos-4-ulose; Xref=Rhea:RHEA:24710, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:58708, ChEBI:CHEBI:58710; EC=2.6.1.87; Evidence={ECO:0000269|PubMed:12429098}; |
| Cofactor: | |
Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000269|PubMed:12429098}; |
| Activity regulation: | |
Inhibited by L-cycloserine. {ECO:0000269|PubMed:12429098}. |
| Pathway: | |
Nucleotide-sugar biosynthesis; UDP-4-deoxy-4-formamido-beta-L- arabinose biosynthesis; UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate: step 2/3. |
| Pathway: | |
Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:12429098, ECO:0000269|PubMed:24460375}. |
| Induction: | |
Induced by BasR. {ECO:0000269|PubMed:10480935}. |
| Similarity: | |
Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.