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UniProt functional annotation for P01556 | ||
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| UniProt code: P01556. |
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| Organism: | |
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio. |
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| Function: | |
The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself. |
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| Subunit: | |
The holotoxin (choleragen) consists of a pentameric ring of B subunits whose central pore is occupied by the A subunit. The A subunit contains two chains, A1 and A2, linked by a disulfide bridge. {ECO:0000269|PubMed:11880036, ECO:0000269|PubMed:3214}. |
| Subcellular location: | |
Secreted. Host cell membrane {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.