|
|
||
|
|
|
|
|
UniProt functional annotation for Q29551 | ||
|
|
|
|
|
|
||
| UniProt code: Q29551. |
|
||
| Organism: | |
Sus scrofa (Pig). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus. |
|
||
|
||
| Function: | |
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. {ECO:0000269|PubMed:17718512, ECO:0000269|PubMed:20977214}. |
|
||
| Catalytic activity: | |
Reaction=a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate; Xref=Rhea:RHEA:24564, ChEBI:CHEBI:30031, ChEBI:CHEBI:35973, ChEBI:CHEBI:57292, ChEBI:CHEBI:90726; EC=2.8.3.5; Evidence={ECO:0000255|PROSITE-ProRule:PRU10034, ECO:0000269|PubMed:17718512, ECO:0000269|PubMed:20977214}; |
| Pathway: | |
Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:12463743, ECO:0000269|PubMed:15388917, ECO:0000269|PubMed:17718512, ECO:0000269|PubMed:20606260, ECO:0000269|PubMed:20977214, ECO:0000269|Ref.5}. |
| Subcellular location: | |
Mitochondrion. |
| Similarity: | |
Belongs to the 3-oxoacid CoA-transferase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.