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UniProt functional annotation for Q9NBG9 | ||
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| UniProt code: Q9NBG9. |
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| Organism: | |
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus. |
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| Function: | |
Alpha-KTx 16.2: inhibits large conductance calcium-activated potassium channels (KCa1.1/Slo-beta4 KCNMA1/KCNMB4). It appears to block channel activity by a simple bimolecular inhibition process. Shows a fast association rate and a slow dissociation rate of binding on rat brain synaptosome (PubMed:18199674). Significantly inhibits voltage-dependent sodium current and voltage-dependent delayed rectifier potassium currents (PubMed:14632928). {ECO:0000269|PubMed:14632928, ECO:0000269|PubMed:18199674}. |
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| Function: | |
[Martentoxin-1]: significantly inhibits voltage-dependent sodium current (Nav) and voltage-dependent delayed rectifier potassium current. {ECO:0000269|PubMed:14632928}. |
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| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Domain: | |
Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta). {ECO:0000269|PubMed:15558557}. |
| Mass spectrometry: | |
[Potassium channel toxin alpha-KTx 16.2]: Mass=4060; Method=Electrospray; Evidence={ECO:0000269|PubMed:12558995}; |
| Mass spectrometry: | |
[Potassium channel toxin alpha-KTx 16.2]: Mass=4056.3; Method=MALDI; Evidence={ECO:0000269|PubMed:14632928}; |
| Mass spectrometry: | |
[Martentoxin-b]: Mass=3852.89; Method=Electrospray; Note=Monoisotopic mass.; Evidence={ECO:0000269|PubMed:22887697}; |
| Mass spectrometry: | |
[Martentoxin-1]: Mass=3908.0; Method=MALDI; Evidence={ECO:0000269|PubMed:14632928}; |
| Similarity: | |
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 16 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.