|
|
||
|
|
|
|
|
UniProt functional annotation for P16184 | ||
|
|
|
|
|
|
||
| UniProt code: P16184. |
|
||
| Organism: | |
Pneumocystis carinii. |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Pneumocystidomycetes; Pneumocystidaceae; Pneumocystis. |
|
||
|
||
| Function: | |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|
||
| Catalytic activity: | |
Reaction=(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH; Xref=Rhea:RHEA:15009, ChEBI:CHEBI:15378, ChEBI:CHEBI:57451, ChEBI:CHEBI:57453, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.5.1.3; Evidence={ECO:0000255|PROSITE- ProRule:PRU00660}; |
| Pathway: | |
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8- tetrahydrofolate from 7,8-dihydrofolate: step 1/1. |
| Similarity: | |
Belongs to the dihydrofolate reductase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.