|
|
||
|
|
|
|
|
UniProt functional annotation for P20718 | ||
|
|
|
|
|
|
||
| UniProt code: P20718. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication. {ECO:0000269|PubMed:22156497, ECO:0000269|PubMed:23269243}. |
|
||
| Activity regulation: | |
Inhibited by SERPINB1. {ECO:0000269|PubMed:23269243}. |
| Subcellular location: | |
Cytolytic granule {ECO:0000269|PubMed:23269243}. |
| Tissue specificity: | |
Constitutively expressed in NK cells. {ECO:0000269|PubMed:23269243}. |
| Similarity: | |
Belongs to the peptidase S1 family. Granzyme subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}. |
Annotations taken from UniProtKB at the EBI.