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UniProt functional annotation for P08148 | ||
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| UniProt code: P08148. |
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| Organism: | |
Leishmania major. |
| Taxonomy: | |
Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina; Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania. |
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| Function: | |
Has an integral role during the infection of macrophages in the mammalian host. |
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| Catalytic activity: | |
Reaction=Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala- Tyr-|-Leu-Lys-Lys-.; EC=3.4.24.36; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:9739094}; |
| Subcellular location: | |
Cell membrane; Lipid-anchor, GPI-anchor. |
| Ptm: | |
The phosphatidylinositol moiety of the GPI-anchor contains a fully saturated, unbranched 1-O-alkyl chain (mainly C24:0) and a mixture of fully saturated unbranched 2-O-acyl chains (C12:0, C14:0, C16:0, and C18:0). |
| Similarity: | |
Belongs to the peptidase M8 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.