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PDBsum entry 1ld2
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References listed in PDB file
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Key reference
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Title
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Structural effects of monovalent anions on polymorphic lysozyme crystals.
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Authors
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M.C.Vaney,
I.Broutin,
P.Retailleau,
A.Douangamath,
S.Lafont,
C.Hamiaux,
T.Prangé,
A.Ducruix,
M.Riès-Kautt.
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Ref.
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Acta Crystallogr D Biol Crystallogr, 2001,
57,
929-940.
[DOI no: ]
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PubMed id
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Abstract
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Understanding direct salt effects on protein crystal polymorphism is addressed
by comparing different crystal forms (triclinic, monoclinic, tetragonal and
orthorhombic) for hen, turkey, bob white quail and human lysozymes. Four new
structures of hen egg-white lysozyme are reported: crystals grown in the
presence of NapTS diffracted to 1.85 A, of NaI to 1.6 A, of NaNO(3) to 1.45 A
and of KSCN to 1.63 A. These new structures are compared with previously
published structures in order to draw a mapping of the surface of different
lysozymes interacting with monovalent anions, such as nitrate, chloride, iodide,
bromide and thiocyanate. An analysis of the structural sites of these anions in
the various lysozyme structures is presented. This study shows common anion
sites whatever the crystal form and the chemical nature of anions, while others
seem specific to a given geometry and a particular charge environment induced by
the crystal packing.
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Figure 4.
Figure 4 R.m.s. deviations versus the sequence number between
the two independent molecules of the HEWL/NaI monoclinic
structure showing the non-equivalence of loops 65-75.
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Figure 6.
Figure 6 All anionic sites (red numbers) aligned on the lysozyme
sequence. The unique sites are labelled according to the
chemical formula of the anion taken from the corresponding PDB
file.
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The above figures are
reprinted
by permission from the IUCr:
Acta Crystallogr D Biol Crystallogr
(2001,
57,
929-940)
copyright 2001.
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Secondary reference #1
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Title
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Transcript mapping in a 46-Kb sequenced region at the core of 12q13.3 amplification in human cancers.
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Authors
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A.G.Elkahloun,
D.B.Krizman,
Z.Wang,
T.A.Hofmann,
B.Roe,
P.S.Meltzer.
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Ref.
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Genomics, 1997,
42,
295-301.
[DOI no: ]
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PubMed id
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Secondary reference #2
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Title
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Homology probing: identification of cdna clones encoding members of the protein-Serine kinase family.
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Author
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S.K.Hanks.
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Ref.
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Proc Natl Acad Sci U S A, 1987,
84,
388-392.
[DOI no: ]
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PubMed id
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Secondary reference #3
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Title
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Coamplification of the cdk4 gene with mdm2 and gli in human sarcomas.
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Authors
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Z.A.Khatib,
H.Matsushime,
M.Valentine,
D.N.Shapiro,
C.J.Sherr,
A.T.Look.
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Ref.
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Cancer Res, 1993,
53,
5535-5541.
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PubMed id
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Secondary reference #4
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Title
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A p16ink4a-Insensitive cdk4 mutant targeted by cytolytic t lymphocytes in a human melanoma.
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Authors
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T.Wölfel,
M.Hauer,
J.Schneider,
M.Serrano,
C.Wölfel,
E.Klehmann-Hieb,
E.De plaen,
T.Hankeln,
K.H.Meyer zum büschenfelde,
D.Beach.
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Ref.
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Science, 1995,
269,
1281-1284.
[DOI no: ]
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PubMed id
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Secondary reference #5
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Title
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Germline mutations in the p16ink4a binding domain of cdk4 in familial melanoma.
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Authors
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L.Zuo,
J.Weger,
Q.Yang,
A.M.Goldstein,
M.A.Tucker,
G.J.Walker,
N.Hayward,
N.C.Dracopoli.
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Ref.
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Nat Genet, 1996,
12,
97-99.
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PubMed id
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Secondary reference #6
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Title
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Structural basis of inhibition of cdk-Cyclin complexes by ink4 inhibitors.
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Authors
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P.D.Jeffrey,
L.Tong,
N.P.Pavletich.
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Ref.
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Genes Dev, 2000,
14,
3115-3125.
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PubMed id
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