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PDBsum entry 1la2
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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Structural analysis of saccharomyces cerevisiae myo-Inositol phosphate synthase.
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Authors
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R.Kniewel,
J.A.Buglino,
V.Shen,
T.Chadha,
A.Beckwith,
C.D.Lima.
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Ref.
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J Struct Funct Genomics, 2002,
2,
129-134.
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PubMed id
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Abstract
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The New York Structural Genomics Research Consortium has targeted highly
conserved but uncharacterized enzyme families for structure determination. As
part of this effort, the 2.65-A crystal structure has been determined for
Saccharomyces cerevisiae myo-inositol 1-phosphate synthase (MIP), an essential
enzyme that catalyzes critical steps in inositol biosynthesis. The structure
determination of four independent monomers in the asymmetric unit (240 kDa)
reveals atomic details and residue composition for the partially closed
NAD-containing active sites in apo-configuration. The structure further reveals
extensive interactions involved in tetrameric assembly of the enzyme complex.
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