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UniProt functional annotation for P94368 | ||
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| UniProt code: P94368. |
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| Organism: | |
Bacillus subtilis (strain 168). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus. |
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| Function: | |
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. {ECO:0000255|HAMAP-Rule:MF_01965}. |
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| Catalytic activity: | |
Reaction=(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate; Xref=Rhea:RHEA:32223, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57945, ChEBI:CHEBI:64074, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=4.2.1.136; Evidence={ECO:0000255|HAMAP- Rule:MF_01965}; |
| Catalytic activity: | |
Reaction=(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate; Xref=Rhea:RHEA:32235, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57783, ChEBI:CHEBI:64076, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=4.2.1.136; Evidence={ECO:0000255|HAMAP- Rule:MF_01965}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-Rule:MF_01965}; |
| Subunit: | |
Homotetramer. {ECO:0000255|HAMAP-Rule:MF_01965, ECO:0000269|PubMed:12457846, ECO:0000269|Ref.4}. |
| Similarity: | |
Belongs to the NnrD/CARKD family. {ECO:0000255|HAMAP- Rule:MF_01965}. |
Annotations taken from UniProtKB at the EBI.