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UniProt functional annotation for P59854 | ||
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| UniProt code: P59854. |
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| Organism: | |
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus. |
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| Function: | |
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active on both mammals and insects. It can be considered as a cardiotoxin, as it can bind to human cardiac sodium channel and modify its normal properties. {ECO:0000269|PubMed:12370033}. |
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| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Domain: | |
Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta). {ECO:0000305}. |
| Mass spectrometry: | |
Mass=7237.4; Method=MALDI; Evidence={ECO:0000269|PubMed:15321715}; |
| Miscellaneous: | |
Exists in two forms, due to cis-trans isomerization at 9-Pro-His-10. |
| Similarity: | |
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.