 |
PDBsum entry 1kpw
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Membrane protein
|
PDB id
|
|
|
|
1kpw
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
References listed in PDB file
|
|
|
Key reference
|
|
|
Title
|
|
Crystal structure of rhodopsin: a template for cone visual pigments and other g protein-Coupled receptors.
|
|
|
Authors
|
|
R.E.Stenkamp,
S.Filipek,
C.A.Driessen,
D.C.Teller,
K.Palczewski.
|
|
|
Ref.
|
|
Biochim Biophys Acta, 2002,
1565,
168-182.
[DOI no: ]
|
|
|
PubMed id
|
|
|
|
|
Note In the PDB file this reference is
annotated as "TO BE PUBLISHED".
The citation details given above were identified by an automated
search of PubMed on title and author
names, giving a
percentage match of
95%.
|
|
|
|
Abstract
|
|
|
The crystal structure of rhodopsin has provided the first three-dimensional
molecular model for a G-protein-coupled receptor (GPCR). Alignment of the
molecular model from the crystallographic structure with the helical axes seen
in cryo-electron microscopic (cryo-EM) studies provides an opportunity to
investigate the properties of the molecule as a function of orientation and
location within the membrane. In addition, the structure provides a starting
point for modeling and rational experimental approaches of the cone pigments,
the GPCRs in cone cells responsible for color vision. Homology models of the
cone pigments provide a means of understanding the roles of amino acid sequence
differences that shift the absorption maximum of the retinal chromophore in the
environments of different opsins.
|
|
|
|
|
|
|
