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UniProt functional annotation for P9WPB7 | ||
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| UniProt code: P9WPB7. |
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| Organism: | |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). |
| Taxonomy: | |
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. |
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| Function: | |
Catalyzes the conversion of a double bond to a cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence. {ECO:0000269|PubMed:7592990}. |
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| Catalytic activity: | |
Reaction=1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L- methionine = 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:11988, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:76593, ChEBI:CHEBI:76594; EC=2.1.1.79; |
| Pathway: | |
Lipid metabolism; mycolic acid biosynthesis. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:11756461}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250}. |
| Similarity: | |
Belongs to the CFA/CMAS family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.