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UniProt functional annotation for P0A6E4 | ||
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| UniProt code: P0A6E4. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Catalytic activity: | |
Reaction=ATP + L-aspartate + L-citrulline = 2-(N(omega)-L- arginino)succinate + AMP + diphosphate + H(+); Xref=Rhea:RHEA:10932, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57472, ChEBI:CHEBI:57743, ChEBI:CHEBI:456215; EC=6.3.4.5; |
| Pathway: | |
Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. |
| Subunit: | |
Homotetramer. {ECO:0000269|PubMed:11738042, ECO:0000269|PubMed:11809762}. |
| Subcellular location: | |
Cytoplasm {ECO:0000305}. |
| Domain: | |
The monomer is composed of two major structural domains: a nucleotide-binding domain and a catalytic/multimerization domain. Binding of ATP results in a large rigid body conformational change of the nucleotide binding domain. |
| Similarity: | |
Belongs to the argininosuccinate synthase family. Type 2 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.