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UniProt functional annotation for P0A0L5 | ||
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| UniProt code: P0A0L5. |
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| Organism: | |
Staphylococcus aureus. |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae; Staphylococcus. |
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| Function: | |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines (PubMed:10229190, PubMed:28849041). Causes also the intoxication staphylococcal food poisoning syndrome (By similarity). {ECO:0000250|UniProtKB:P34071, ECO:0000269|PubMed:10229190, ECO:0000269|PubMed:28849041}. |
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| Subunit: | |
Interacts with MHC class II molecules composed of alpha/HLA- DRA and beta/HLA-DRB1 chains (PubMed:10229190). Interacts with host T- cell receptor/TCR beta variable chain TRBV8-2 (PubMed:10229190, PubMed:20836565). {ECO:0000269|PubMed:10229190, ECO:0000269|PubMed:20836565}. |
| Subcellular location: | |
Secreted. |
| Similarity: | |
Belongs to the staphylococcal/streptococcal toxin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.