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UniProt functional annotation for P04746 | ||
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| UniProt code: P04746. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Catalytic activity: | |
Reaction=Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D- glucose units.; EC=3.2.1.1; Evidence={ECO:0000269|PubMed:10091666, ECO:0000269|PubMed:10769135, ECO:0000269|PubMed:11772019, ECO:0000269|PubMed:11914097}; |
| Cofactor: | |
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:10091666, ECO:0000269|PubMed:10769135, ECO:0000269|PubMed:11772019, ECO:0000269|PubMed:11914097, ECO:0000269|PubMed:8528071}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000269|PubMed:10091666, ECO:0000269|PubMed:10769135, ECO:0000269|PubMed:11772019, ECO:0000269|PubMed:11914097, ECO:0000269|PubMed:8528071}; |
| Cofactor: | |
Name=chloride; Xref=ChEBI:CHEBI:17996; Evidence={ECO:0000269|PubMed:10091666, ECO:0000269|PubMed:10769135, ECO:0000269|PubMed:11772019, ECO:0000269|PubMed:11914097, ECO:0000269|PubMed:8528071}; Note=Binds 1 Cl(-) ion per subunit. {ECO:0000269|PubMed:10091666, ECO:0000269|PubMed:10769135, ECO:0000269|PubMed:11772019, ECO:0000269|PubMed:11914097, ECO:0000269|PubMed:8528071}; |
| Subunit: | |
Monomer. |
| Subcellular location: | |
Secreted, extracellular space. |
| Tissue specificity: | |
Detected in pancreas (at protein level). {ECO:0000269|PubMed:8528071}. |
| Similarity: | |
Belongs to the glycosyl hydrolase 13 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.