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UniProt functional annotation for O69274 | ||
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| UniProt code: O69274. |
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| Organism: | |
Corynebacterium ammoniagenes (Brevibacterium ammoniagenes). |
| Taxonomy: | |
Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae; Corynebacterium. |
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| Function: | |
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. {ECO:0000256|PIRNR:PIRNR000355}. |
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| Catalytic activity: | |
Reaction=[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'- diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'- diphosphate; Xref=Rhea:RHEA:23252, Rhea:RHEA-COMP:10698, Rhea:RHEA- COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57930, ChEBI:CHEBI:73316; EC=1.17.4.1; Evidence={ECO:0000256|PIRNR:PIRNR000355}; |
| Cofactor: | |
Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000256|ARBA:ARBA00001962}; |
| Cofactor: | |
Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000256|PIRNR:PIRNR000355, ECO:0000256|PIRSR:PIRSR000355-2}; Note=Binds 2 iron ions per subunit. {ECO:0000256|PIRNR:PIRNR000355, ECO:0000256|PIRSR:PIRSR000355-2}; |
| Pathway: | |
Genetic information processing; DNA replication. {ECO:0000256|ARBA:ARBA00005160, ECO:0000256|PIRNR:PIRNR000355}. |
| Subunit: | |
Tetramer of two alpha and two beta subunits. {ECO:0000256|ARBA:ARBA00011209}. |
| Similarity: | |
Belongs to the ribonucleoside diphosphate reductase small chain family. {ECO:0000256|ARBA:ARBA00009303, ECO:0000256|PIRNR:PIRNR000355}. |
Annotations taken from UniProtKB at the EBI.