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UniProt functional annotation for P29588 | ||
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| UniProt code: P29588. |
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| Organism: | |
Methanothermobacter thermautotrophicus (Methanobacterium thermoformicicum). |
| Taxonomy: | |
Archaea; Euryarchaeota; Methanomada group; Methanobacteria; Methanobacteriales; Methanobacteriaceae; Methanothermobacter. |
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| Function: | |
DNA glycosylase that excises thymine from T/G mismatches and uracil from U/G mismatches (PubMed:8895589, PubMed:11788726). Acts as a repair enzyme able to counteract the mutagenic effect of spontaneous hydrolytic deamination of DNA 5-methylcytosine (5-meC) residues that leads to the formation of T/G mismatches (PubMed:8895589). May also repair U/G mismatches arising from hydrolytic deamination of DNA cytosine residues (PubMed:8895589). G/G, A/G, T/C and U/C are minor substrates (PubMed:8895589, PubMed:11788726). {ECO:0000269|PubMed:11788726, ECO:0000269|PubMed:8895589}. |
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| Catalytic activity: | |
Reaction=Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine.; EC=3.2.2.29; Evidence={ECO:0000269|PubMed:11788726, ECO:0000269|PubMed:8895589}; |
| Cofactor: | |
Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000250|UniProtKB:P83847}; Note=Binds 1 [4Fe-4S] cluster. The cluster has a structural role. {ECO:0000250|UniProtKB:P83847}; |
| Similarity: | |
Belongs to the Nth/MutY family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.