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UniProt functional annotation for O18734 | ||
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| UniProt code: O18734. |
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| Organism: | |
Sus scrofa (Pig). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus. |
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| Function: | |
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. {ECO:0000269|PubMed:10869555, ECO:0000269|PubMed:10924361, ECO:0000269|PubMed:8720121, ECO:0000269|PubMed:9237662}. |
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| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:11517233}. |
| Tissue specificity: | |
Detected in aorta smooth muscle and bladder. {ECO:0000269|PubMed:9237662}. |
| Ptm: | |
Phosphorylation of Thr-38 induces a conformation change. {ECO:0000269|PubMed:10869555, ECO:0000269|PubMed:10924361, ECO:0000269|PubMed:8720121}. |
| Similarity: | |
Belongs to the PP1 inhibitor family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.