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UniProt functional annotation for P62593 | ||
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| UniProt codes: P62593, P00810. |
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| Organism: | |
Escherichia coli. |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM- 16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT- 4 shows resistance to beta-lactamase inhibitors. |
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| Catalytic activity: | |
Reaction=a beta-lactam + H2O = a substituted beta-amino acid; Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627, ChEBI:CHEBI:140347; EC=3.5.2.6; Evidence={ECO:0000255|PROSITE- ProRule:PRU10101}; |
| Biotechnology: | |
This protein is used as a marker in many commonly used cloning vectors, such as pBR322 and the pUC series. |
| Miscellaneous: | |
The beta-lactamase present on pBR322 was cloned from plasmid R1 (R7268). |
| Similarity: | |
Belongs to the class-A beta-lactamase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.