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UniProt functional annotation for P0A6F5 | ||
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| UniProt codes: P0A6F5, P06139. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. |
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| Function: | |
Essential for the growth of the bacteria and the assembly of several bacteriophages. Also plays a role in coupling between replication of the F plasmid and cell division of the cell. |
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| Subunit: | |
Oligomer of 14 subunits composed of two stacked rings of 7 subunits. Complex can be destablized when Ala-2 and Glu-76 are mutated to match these residues in M.tuberculosis (PubMed:15327959). {ECO:0000269|PubMed:15327959}. |
| Subcellular location: | |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00600, ECO:0000269|PubMed:20094032, ECO:0000269|PubMed:22380631}. Note=Uniformly located in the cytoplasm (PubMed:20094032). Exclusively localized in foci, usually near 1 cell pole in mid-to-late exponential phase (PubMed:22380631); polar localization depends on the minCDE operon. Foci form near midcell (Probable). {ECO:0000269|PubMed:20094032, ECO:0000269|PubMed:22380631, ECO:0000305}. |
| Ptm: | |
Phosphorylated reversibly during heat shock. {ECO:0000269|PubMed:1349729}. |
| Miscellaneous: | |
This protein shows ATPase activity. |
| Similarity: | |
Belongs to the chaperonin (HSP60) family. {ECO:0000255|HAMAP-Rule:MF_00600}. |
| Sequence caution: | |
Sequence=AAA23934.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.