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UniProt functional annotation for Q8RPQ1 | ||
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| UniProt code: Q8RPQ1. |
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| Organism: | |
Bacillus anthracis. |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus; Bacillus cereus group. |
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| Function: | |
Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton Fe(2+) ion (By similarity). It is capable of binding and sequestering Fe(2+) ion. Does not bind DNA. {ECO:0000250}. |
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| Catalytic activity: | |
Reaction=2 Fe(2+) + 2 H(+) + H2O2 = 2 Fe(3+) + 2 H2O; Xref=Rhea:RHEA:48712, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; |
| Subunit: | |
The 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe(3+) can be deposited (By similarity). Homododecamer. {ECO:0000250, ECO:0000269|PubMed:11836250}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250}. |
| Domain: | |
12 di-nuclear ferroxidase centers are located at the interfaces between subunits related by 2-fold symmetry axes. |
| Similarity: | |
Belongs to the Dps family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.