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UniProt functional annotation for P00949 | ||
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| UniProt code: P00949. |
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| Organism: | |
Oryctolagus cuniculus (Rabbit). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus. |
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| Function: | |
This enzyme participates in both the breakdown and synthesis of glucose. |
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| Catalytic activity: | |
Reaction=alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate; Xref=Rhea:RHEA:23536, ChEBI:CHEBI:58225, ChEBI:CHEBI:58601; EC=5.4.2.2; Evidence={ECO:0000269|PubMed:1328221}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:15299905}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000269|PubMed:15299905}; |
| Subunit: | |
Monomer. {ECO:0000269|PubMed:6223925}. |
| Subcellular location: | |
[Isoform 1]: Cytoplasm. |
| Subcellular location: | |
[Isoform 2]: Sarcoplasmic reticulum {ECO:0000269|PubMed:1328221}. Note=Localizes to the junctional skeletal sarcoplasmic reticulum, probably by association with phospholipids and/or other proteins. {ECO:0000269|PubMed:1328221}. |
| Ptm: | |
Isoform 2 is the major calmodulin-dependent phosphoprotein in junctional skeletal sarcoplasmic reticulum vesicles. {ECO:0000269|PubMed:1328221}. |
| Ptm: | |
Phosphorylation at Thr-467 by PAK1 significantly enhances enzymatic activity. {ECO:0000250|UniProtKB:P36871}. |
| Similarity: | |
Belongs to the phosphohexose mutase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.